Napoli need a victory tonight against Villarreal to stay in the Europa League, so Gonzalo Higuain is given a rare midweek start.
It kicks off at the Stadio San Paolo at 20.05 GMT, follow all the action as it happens from this game and Tottenham-Fiorentina on our LIVEBLOG.
The first leg in this Round of 32 ended 1-0 for the Yellow Submarine thanks to a late Denis Suarez free kick.
Napoli need a victory tonight against Villarreal to stay in the Europa League, so Gonzalo Higuain is given a rare midweek start.
It kicks off at the Stadio San Paolo at 20.05 GMT, follow all the action as it happens from this game and Tottenham-Fiorentina on our LIVEBLOG.
The first leg in this Round of 32 ended 1-0 for the Yellow Submarine thanks to a late Denis Suarez free kick.
Before that fixture, Napoli had a perfect record in the competition this season with 22 goals scored and only three conceded.
The Partenopei are unbeaten in 16 European home games, including 12 victories, since defeat to Viktoria Plzen in 2012-13.
Faouzi Ghoulam, Omar El Kaddouri and Nathaniel Chalobah are unavailable, while Maurizio Sarri shelves his squad rotation ahead of Monday’s huge Serie A clash with third-placed Fiorentina.
That means Higuain gets a rare start in the Europa League, flanked by Lorenzo Insigne and Dries Mertens, resting exhausted Jose Callejon.
Marek Hamsik and Mirko Valdifiori partner up in midfield, resting Jorginho and Allan.
Napoli are without a win in three competitive games, their worst streak of the season.
Villarreal have scored in each of their last 11 European away fixtures, but Jonathan Dos Santos is out after sustaining a serious hamstring injury in the first leg.
Samuel Castillejo was expected to step in, but Antonio Rukavina, Tomas Pina and Cedric Bakambu are given surprise starts.
Javier Jimenez sits out a ban and Samu is also injured.
No Spanish side has ever beaten Napoli at the San Paolo in a competitive game, managing three draws from five visits.
Villarreal have never won on Italian soil, losing five and drawing three.
Napoli: Reina; Hysaj, Albiol, Chiriches, Strinic; David Lopez, Valdifiori, Hamsik; Insigne, Higuain, Mertens
Napoli bench: Gabriel, Maggio, Koulibaly, Allan, Jorginho, Callejon, Gabbiadini
Villarreal: Areola; Mario Gaspar, Musacchio, Victor Ruiz, Jaume Costa; Rukavina, Pina, Bruno Soriano, Suarez; Soldado, Bakambu
Villarreal bench: Sergio Asenjo, Bonera, Bailly, Trigueros, Castillejo, Baptistao, Adrian Lopez