Inter revamp again with Marcelo Brozovic, Eder, Adem Ljajic, Ivan Perisic and Mauro Icardi against giant-killers Bologna.
It kicks off at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
The Nerazzurri are still in the running for that third Champions League spot and are closing on Fiorentina in fourth too.
However, Bologna have caused numerous upsets this season, beating Napoli and Milan, while they are also the only Serie A side to have stopped Juventus winning since October 28.
Roberto Donadoni can count on several ex-Inter players, such as Mattia Destro, Ibrahima Mbaye and Saphir Taider.
Emanuele Giaccherini also starts in the trident attack, while Godfred Donsah and Assane Diawara are remarkable teenage talents in midfield.
Anthony Mounier is unavailable after coming down with flu.
Roberto Mancini is tinkering with his line-up again, opting for a 4-2-3-1 that can use Eder, Ljajic and Perisic supporting lone centre-forward Icardi.
Brozovic gets the nod in midfield ahead of Geoffrey Kondogbia, as Felipe Melo is benched yet again.
Stevan Jovetic is the only injury absentee for the Nerazzurri ahead of next week’s showdown with Roma.
Bologna have an excellent recent record in this fixture, unbeaten here since a 4-1 result in January 2011.
Last season they fought back twice against an Icardi brace for a thrilling 2-2 draw.
The Rossoblu had won twice before then, 1-0 in March 2013 and 3-0 in February 2012.
Inter: Handanovic; D'Ambrosio, Miranda, Juan Jesus, Nagatomo; Medel, Brozovic; Eder, Ljajic, Perisic; Icardi
Inter bench: Carrizo, Berni, Kondogbia, Palacio, Biabiany, Telles, Santon, Murillo, Gnoukouri, Melo, Manaj
Bologna: Mirante; Mbaye, Gastaldello, Maietta, Masina; Donsah, Diawara, Taider; Rizzo, Destro, Giaccherini
Bologna bench: Da Costa, Stojanovic, Oikonomou, Morleo, Pulgar, Zuniga, Rossettini, Constant, Brienza, Brighi, Floccari