Milan host battling Carpi at San Siro with Kevin-Prince Boateng in a new role behind Carlos Bacca and Mario Balotelli.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
New Coach Cristian Brocchi made a positive debut in last week’s 1-0 win away to Sampdoria, having replaced sacked Sinisa Mihajlovic.
He immediately changed tactics to a 4-3-1-2 formation, but there are already adjustments for this second test.
Juraj Kucka is suspended with Andrea Bertolacci, Luiz Adriano and M’Baye Niang suspended, so Boateng is given a surprise start behind strikers Bacca and Balotelli.
SuperMario was very impressive against Samp and may well be proving himself in time to earn a permanent Milan move from Liverpool.
Jack Bonaventura therefore moves to a deeper role, having sat in the ‘hole’ last time out.
Carpi can take advantage of the midweek results to break away from the relegation zone, but go into San Siro without Zeljko Brkic, Igor Bubnjic and suspended Riccardo Gagliolo.
Jonathan De Guzman makes a surprise start behind Jerry Mbakogu with ex-Milan man Cristian Zaccardo in defence.
These sides have only ever crossed paths twice before, a 0-0 Serie A draw in December and January’s 2-1 Coppa Italia Milan victory at San Siro.
Bacca bagged a brace that day before Matteo Mancosu’s reply.
Milan: Donnarumma; Abate, Alex, A Romagnoli, Antonelli; Poli, Montolivo, Bonaventura; Boateng; Balotelli, Bacca
Milan bench: Abbiati, Diego Lopez, Calabria, De Sciglio, Ely, Mexes, Zapata, J.Mauri, Locatelli, Honda, Menez, Vido
Carpi: Belec; Zaccardo, S Romagnoli, Suagher; Sabelli, Crimi, Cofie, Martinho, Letizia; De Guzman; Mbakogu
Carpi bench: Colombi, Poli, Daprelà, Porcari, Di Gaudio, Lollo, Pasciuti, Fedele, Bianco, Verdi, Lasagna, Mancosu