Crotone and Pescara go head-to-head in a massive relegation dogfight at the foot of the table.
It kicks off at the Stadio Scida at 17.00 GMT, follow the action as it happens on our Liveblog.
Only two points separate these sides, who sit in two of the bottom three positions.
In real terms, Pescara would be last on five points, but they were given a 3-0 win against Sassuolo for the fielding of an ineligible player.
Crotone and Pescara go head-to-head in a massive relegation dogfight at the foot of the table.
It kicks off at the Stadio Scida at 17.00 GMT, follow the action as it happens on our Liveblog.
Only two points separate these sides, who sit in two of the bottom three positions.
In real terms, Pescara would be last on five points, but they were given a 3-0 win against Sassuolo for the fielding of an ineligible player.
The Delfini ended a run of seven straight defeats with their late 1-1 draw against 10-man Cagliari last week.
Jean-Christophe Bahebeck and Andrea Coda are still sidelined, but Alberto Aquilani and Hugo Campagnaro are available again.
As for the Squali, they have Lorenzo Crisetig and Aleandro Rosi suspended, plus Djamel Mesbah, Claiton Dos Santos and Aleksandar Tonev injured.
Crotone came within four minutes of getting a point away to second-placed Milan last week, so confidence is growing, particularly for striker Diego Falcinelli, who has been responsible for their last three goals.
Expect goals, because these are some of the worst defences in Serie A, conceding 29 and 27 respectively.
Both teams were promoted over the summer and last season in Serie B got a home win each: 4-1 for Pescara and 4-2 for Crotone.
Crotone: Cordaz; Sampirisi, Ceccherini, Ferrari, Martella; Rohden, Capezzi, Barberis; Falcinelli, Trotta, Palladino
Pescara: Bizzarri; Zampano, Gyomber, Campagnaro, Crescenzi; Memushaj, Brugman, Verre; Benali, Pepe, Caprari