Edin Dzeko and Diego Perotti take on Gianluca Lapadula and Suso as Roma and Milan go head-to-head for second place.
These two sides are currently locked together in second spot and whoever wins will emerge as the early Scudetto challengers to leaders Juventus.
Roma are fresh from a hard-fought 2-0 Derby della Capitale victory over Lazio, which dominated the last few days because of a two-match ban imposed on Kevin Strootman for provoking and then simulating a touchline tussle with Danilo Cataldi.
The Dutchman won his emergency appeal to have the ban revoked, as it would’ve ruled him out of both this game and the trip to Juventus.
Instead, Strootman starts with Daniele De Rossi in midfield, supporting Radja Nainggolan, Diego Perotti and Capocannoniere Edin Dzeko.
There were reports Stephan El Shaarawy would start against his old club, but instead Bruno Peres is passed fit and starts with Emerson Palmieri in a 3-4-1-2 formation.
Mohamed Salah, Leandro Paredes, Alessandro Florenzi and Francesco Totti are in the stands.
Milan must do without suspended Juraj Kucka and injured Carlos Bacca, Giacomo Bonaventura, Riccardo Montolivo and Davide Calabria.
Therefore Mario Pasalic and Lapadula again start after their goals to beat Crotone 2-1, while Andrea Bertolacci makes his comeback from a thigh injury in midfield after playing just five minutes in the opening game against Torino on August 21.
Despite rumours of Keisuke Honda starting, M’Baye Niang does complete the trident with Gianluca Lapadula and Suso.
It’s a return to the Stadio Olimpico for ex-Roma players Bertolacci and Alessio Romagnoli, as well as Coach Vincenzo Montella.
Milan have won just one of their last 12 visits to the Stadio Olimpico in all competition, a 3-2 thriller in October 2011, along with six draws and five defeats.
The last two editions of this fixture have been stalemates.
Roma: Szczesny; Manolas, Fazio, Rüdiger; Peres, De Rossi, Strootman, Emerson; Nainggolan; Perotti, Dzeko
Roma bench: Alisson, Greco, Vermaelen, Juan Jesus, Mario Rui, Seck, Gerson, Spinozzi, Iturbe, El Shaarawy
Milan: Donnarumma; Abate, Paletta, Romagnoli, De Sciglio; Pasalic, Locatelli, Bertolacci; Suso, Lapadula, Niang
Milan bench: Gabriel, Plizzari, Zapata, Gomez, Ely, Antonelli, Vangioni, Poli, Mati Fernandez, Honda, Luiz Adriano, Sosa