Crotone will hope to come away with all three points when they travel North to face Chievo and keep their slight chance of salvation alive.
A clash of civilizations. Twice in a span of just four days. When Napoli host Juventus, it means football war. And this time, Gonzalo Higuain returns ‘home’.
Milan will be hoping to put more pressure on the sides in European places and push Pescara closer to the drop.
Saturday night sees Roma host Empoli at the Stadio Olimpico, a game of two sides who are almost binary opposites in terms of form.
Lazio have two crucial games coming up, but cannot risk a costly slip-up against a Sassuolo side seeking revitalisation.
Torino will be seeking to get back on track after the international hiatus as they welcome Udinese on Sunday.