Atalanta and Roma begin the campaign eager to continue the success of last term, but with vastly changed sides.
Hosts Bologna are coming into this Serie A season opener off the back of an embarrassing 3-0 home defeat to Serie B outfit Cittadella in the Coppa Italia last week.
Milan swept aside all before them in the Europa League, but now the new-look Rossoneri host Serie A miracle side Crotone.
Reunions at San Siro, as Stefano Pioli returns to face former employers Inter, whilst Borja Valero and Matias Vecino take on Fiorentina.
Juventus swept Cagliari aside 3-0 in the League opener, but Gigi Buffon also saved the first Serie A penalty awarded via VAR.
Fresh off their 3-2 Supercoppa win over Juventus, Lazio begin their Serie A campaign at home to newly-promoted side Spal.
Benevento begin their first ever Serie A campaign in the imposing atmosphere of Marassi against Sampdoria.
New Sassuolo Coach Cristian Bucchi looks to get the campaign off to a perfect start when welcoming Genoa to the Mapei Stadium.
Two teams that finished relatively comfortably mid-table last season will hope to start the new term off well as they lock horns on Sunday evening.
Napoli started Serie A with a bang, conquering Verona 3-1 at the Bentegodi with an inspirational Lorenzo Insigne, but Elseid Hysaj saw red.