Atalanta will look to cap off their fairy-tale season with a victory over Chievo, potentially snatching fourth place from Lazio.
Over the last week, Juventus have wrapped up the Scudetto and Coppa Italia, so visit Bologna in preparation for Real Madrid.
Cagliari play their final competitive game at the Stadio Sant’Elia and host Milan fresh from European qualification.
A disappointing season comes to an end at the Stadio Artemio Franchi, with Fiorentina and Pescara having nothing to play for bar pride.
Inter conclude a bitterly disappointing campaign and the fans are expected to stage more inventive protests when Udinese come to San Siro.
Empoli need to match Crotone’s result against Lazio to guarantee top flight football next season and not join Palermo in Serie B.
Roma can secure second place with a victory on what will be the final game for Francesco Totti and Luciano Spalletti.
Napoli still have an outside chance of taking that precious second place from Roma, and making Dries Mertens Capocannoniere, as they visit Sampdoria.
Andrea Belotti still has an outside chance of becoming Capocannoniere if Torino have a thriller with on-form Sassuolo.