This is a mid-table tussle, as only two points separate Chievo and Bologna going into the Stadio Bentegodi.
Crotone are still in search of their first Serie A victory and visit a Fiorentina side who broke their goal drought in style.
Milan had the chance to go top of the table, but crashed to a 3-0 defeat at Genoa with Gabriel Paletta sent off for a reckless tackle.
This could well be the final Frank de Boer game on the Inter bench and he hosts Sinisa Mihajlovic’s on-form Torino.
Juventus face a striker shortage and are fresh from their second defeat of the season, hosting a revitalised Sampdoria.
Lazio will look to maintain their good record against Cagliari as they take on the Rossoblu.
Napoli’s striker problem just got even worse, but they host an Empoli side seemingly incapable of scoring.
Just as Udinese seem to be finding their feet under new Coach Gigi Del Neri, they visit a Palermo side leaking goals in a relegation tussle.
A still floundering Pescara will be up against it when they welcome an Atalanta side slowly growing in confidence this Wednesday.
Roma are flying high in second place, just two points off leaders Juventus, and visit injury-hit Sassuolo.