Inter travel to Bergamo to face an in-form Atalanta team, hoping to put an end to their three-round winless streak.
Not only is this an Emilia-Romagna Derby, it also pits Sassuolo Coach Eusebio Di Francesco against his son, Bologna striker Federico.
Looking at current form rather than reputation, Fiorentina face a tricky encounter away to Cagliari.
Napoli are dangerously close to freefall at present and visit a Crotone side who finally get the first Serie A game at the Stadio Scida.
Empoli head in to their encounter with Chievo sporting the joint-worst attack in Europe’s top five Leagues.
This fixture hasn’t been so vital for many years, but it’s second against first and could blow the title race open.
Second-place Roma host struggling Palermo at the Olimpico as they look to pressure Juventus and maintain a good run of form.
Sampdoria and Genoa face-off at Stadio Luigi Ferraris with Saturday’s hosts struggling to hold onto their city rivals’ coattails.
Ciro Immobile returns to the club at which he made his name as Torino host Lazio in a head-to-head for Europe.
After five winless weeks each, Udinese and Pescara are now lurking just off the relegation spots, struggling in 16th and 17th position respectively.