After an encouraging performance away to Juventus, Benevento will be aiming to secure their first Serie A points against a depleted Sassuolo side.
Davide Ballardini begins his third tenure in charge of Genoa when his side head to Crotone in what could be a crucial result for the relegation race.
The Lombardy Derby finds Inter still unbeaten and hoping to recapture second or even first place, but hosting surprise outfit Atalanta.
After dropping points for just the second time this season before the international break, Napoli are looking to get things back on track when they host Milan.
For the first time in what feels like years, Roma and Lazio go head-to-head as evenly-matched sides pushing for the top spots.
As Serie A returns, two form sides in Sampdoria and Juventus face off at the Stadio Luigi Ferraris on Sunday afternoon.
Fiorentina will be hoping to bounce back when they head to Emilia-Romagna to take on this season’s Serie A newbies, SPAL.
Sinisa Mihajlovic will be hoping that the grit and determination shown Torino in their 1-1 draw with Inter wasn’t a flash in the pan when they host Chievo.
Diego Lopez is hoping to break the Cagliari jinx at the Dacia Arena in what has become an unexpected relegation tussle.
With both Verona and Bologna coming off five consecutive defeats, something’s got to give at the Bentegodi on Monday night.