While Atalanta have found their feet after a stuttering start to the season, the same cannot be said of Crotone.
Roma will want to gain some confidence and momentum by inflicting a fifth consecutive defeat on Benevento.
Inter saw their 100 per cent record come to an end, as Mauro Icardi’s controversial late penalty wiped out a Simone Verdi screamer in Bologna.
Cagliari are coming into their home game against Sassuolo off the back of a well-deserved 2-0 win over newly promoted SPAL.
Genoa will aim to get off the mark at home as they host Chievo during Serie A’s first midweek round of the season.
Juventus host Fiorentina in what should be the Bianconeri’s first real test of the Serie A season.
Lazio host Napoli at the Stadio Olimpico on Wednesday in a mouth-watering clash between two of the form sides in Serie A.
Big-spending Milan try to keep the pressure up on the top places, but Spal have already caused one upset this season.
This week marks the first midweek matchday in Serie A, and Udinese face Torino at the Stadio Friuli on Wednesday.
Hellas Verona are still after their first win of the new campaign, as they host unbeaten Sampdoria on Wednesday evening.