It stands to be an intriguing battle in Bergamo as outside Europa League hopefuls Atalanta host stuttering Fiorentina.
Empoli will be hoping to gain their first points of the season when they visit fellow new boys Cesena in Week 3.
Chievo look to continue their winning streak as they welcome Parma on Sunday afternoon in Week 3 action.
Genoa entertain Lazio this Sunday in Week 3 of Serie A, hoping to keep up their hex on the visitors.
Milan and Juventus head into a top-of-the-table clash both looking to maintain 100 per cent starts to the Serie A season.
Still without a win since their return to Serie A, Palermo will be hoping history can repeat itself when they host Inter on Sunday.
Zdenek Zeman returns to the Stadio Olimpico with Cagliari to face Roma, the team he has managed on two separate occasions.
Sassuolo will welcome Sampdoria on Sunday after suffering a horrible case of déjà vu in their meeting with Inter in Week 2.
Torino and Verona shined last year, but the Granata have had a difficult start to this season, while the Scaligeri aim to keep their positive pace.
Udinese and Napoli go into their Week 3 meeting level on points and in similar form, but with more pressure on the visitors.