Udinese rely on Antonio Di Natale and Diego Fabbrini for their Europa League match with Rennes.
Coach Francesco Guidolin said in no uncertain terms that Serie A was the priority after the Friulani lost the Champions League play-off with Arsenal, slipping into the other competition.
Top scorer Di Natale was expected to be rested ahead of this weekend's domestic meeting with Fiorentina.
However, the captain is in the starting XI along with Under-21 international Fabbrini, while Mauricio Isla and Pablo Armero return after missing Lecce due to fatigue from international duty.
Gabriel Torje is cup-tied, so cannot follow on from his sparkling performance last Sunday.
Udinese: Handanovic; Isla, Neuton, Danilo, Benatia; Armero, Badu, Abdi, Doubai; Fabbrini; Di Natale
Udinese bench: Padelli, Basta, Domizzi, Ekstrand, Asamoah, Pereyra, Barreto
Rennes: Costil; Danze', Mangane, Boye, Mavinga; Tettey, M'Vila; Kembo-Ekoko, Dalmat, Pitroipa; Hadji
Rennes bench: Diallo, Theophile-Catherine, Kana-Biyik, Boukari, Mandjeck, Doumbia, Montano