Juventus give Fabio Grosso, Arturo Vidal and Eljero Elia starts in their match against Catania.
The Bianconeri hope to keep hold of the Serie A top spot, but face a tricky trip to Sicily, where Catania have a very solid record.
Mirko Vucinic was sent off during the midweek 1-1 draw with Bologna and is therefore suspended, joining the injured Vincenzo Iaquinta.
It prompts Antonio Conte to reshuffle again, giving Vidal his first start and Dutch international Elia his debut in a Juventus jersey.
Catania suffered their first defeat of the season on Wednesday in a 3-0 thumping at the hands of Genoa.
Cristian Llama, Marco Biagianti, Alessandro Potenza and ex-Juve defender Nicola Legrottaglie all missed out.
Coach Vincenzo Montella surprisingly opted to leave Maxi Lopez, Adrian Ricchiuti, Pablo Ledesma and David Suazo on the bench.
Catania: Andujar; Alvarez, Bellusci, Spolli, Capuano; Lodi, Almiron, Delvecchio, Catellani; Bergessio, Gomez
Catania bench: Kosicky, Marchese, Ricchiuti, Ledesma, Lanzafame, Maxi Lopez, Suazo
Juventus: Buffon; Lichtsteiner, Barzagli, Chiellini, Grosso; Marchisio, Pirlo; Krasic, Matri, Vidal, Elia
Juventus bench: Storari, Bonucci, Pazienza, Pepe, Giaccherini, Quagliarella, Del Piero
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