Claudio Ranieri picks Giampaolo Pazzini, Diego Milito and Ricky Alvarez for Inter's Champions League trip to CSKA Moscow.
The Nerazzurri need to get back on track quickly after losing their opener 1-0 at home to Trabzonspor and kick off at the Luzhniki Stadium at 17.00 UK time.
They notched up their first win of the season in all competition by beating Bologna 3-1 on Saturday, but an injury crisis continues to rule out Wesley Sneijder, Dejan Stankovic, Andrea Ranocchia, Ivan Cordoba, Thiago Motta, Douglas Maicon, Emiliano Viviano and the cup-tied Diego Forlan.
Luc Castaignos, Sulley Muntari and Andrea Poli were also left off the UEFA list by previous Coach Gian Piero Gasperini.
Pazzini and Milito both scored at the weekend and are fielded together in the starting XI with Alvarez, who takes over the trequartista role. Joel Obi has recovered from a knock and Javier Zanetti is again in midfield.
CSKA Moscow have their own injury problems, as Igor Akinfeev, Keisuke Gonda, Viktor Vasin, Tomas Necid, Georgi Schennikov and Mark Gonzalez are absent.
These teams have faced off twice in recent seasons, with Inter winning all four legs.
CSKA Moscow: 30 Gabulov; 14 Nababkin, 24 V. Berezutski, 4 Ignashevich, 6 A. Berezutski; 22 Aldonin; 26 Oliseh, 10 Dzagoev, 9 Vagner Love, 17 Mamaev; 8 Doumbia
CSKA Moscow bench: 1 Chepchugov, 2 Semberas, 19 Cauna, 21 Tosic, 25 Rahimic, 48 Popov, 59 Fedetov
Inter: 1 Julio Cesar; 55 Nagatomo, 6 Lucio, 25 Samuel, 26 Chivu; 4 Zanetti, 19 Cambiasso, 20 Obi; 11 Alvarez; 7 Pazzini, 22 Milito
Inter bench: 12 Castellazzi, 16 Caldirola, 42 Jonathan, 48 Crisetig, 29 Coutinho, 28 Zarate, 94 Romanò