Milan welcome back Zlatan Ibrahimovic with Antonio Cassano for their Champions League test with Viktoria Plzen.
The Rossoneri hope to notch up their first victory of the European campaign at San Siro in the 19.45 UK time kick-off, but are in the middle of an injury crisis.
Robinho, Alexandre Pato, Kevin-Prince Boateng, Philippe Mexes and the suspended Gennaro Gattuso are out of action.
Pippo Inzaghi and Stephan El Shaarawy were not placed on the UEFA list, while Ibrahimovic and Luca Antonini are making their comebacks from injury.
Ibra only started taking part in full training sessions on Monday after a thigh strain, while Daniele Bonera is also back for a spot on the bench.
Urby Emanuelson is surprisingly picked ahead of Alberto Aquilani and could take the trequartista role, even though it'll be ‘shared' with Clarence Seedorf.
Czech outfit Viktoria Plzen are in their first ever Champions League campaign and only miss goalkeeper Roman Pavlik, who has been sidelined since picking up a knee injury in July.
They cannot be underestimated, as in the preliminary rounds they won 1-0 away to Rosenborg and 3-1 at FC Copenhagen.
Milan: Abbiati; Abate, Nesta, Thiago Silva, Antonini; Nocerino, Van Bommel, Seedorf; Emanuelson; Cassano, Ibrahimovic
Milan bench: Amelia, Taiwo, Bonera, De Sciglio, Yepes, Aquilani, Ganz
Viktoria Plzen: Cech; Rajtoral, Cisovsky, Bystron, Limbersky; Pilar, Jiracek, Horvath, Kolar, Petrzela; Bakos
Viktoria bench: Pavlik, Reznik, Sevinsky, Trapp, Fillo, Darida, Duris