Lazio have Tommaso Rocchi partnering Miroslav Klose in their front line against Sporting Lisbon.
The Biancocelesti face a tricky trip to Portugal in the Europa League game, which kicks off at 20.05 UK time.
Lorik Cana gets a rare start, while Hernanes takes the trequartista role behind veteran strikers Rocchi and Klose.
Sporting Lisbon go with a 4-4-2 system, as Andre Carrillo partners Ricky Van Wolfswinkel.
The Portuguese giants also field Oguchi Onyewu, the American international defender who had a very brief and unlucky spell at Milan.
Ex-Lecce, Juventus and Fiorentina striker Valeri Bojinov is on the bench.
Sporting Lisbon: Rui Patricio; Joao Pereira, Onyewu, Polga, Insua; Rinaudo, Schaars, Fernandez, Capel; Carrillo, Van Wolfswinkel
Sporting bench: Marcelo, Daniel Carrico, Evaldo, Andre Santos, Andre Martins, Bojinov, Diego Rubio
Lazio: Marchetti; Konko, Dias, Diakhitè, Lulic; Gonzalez, Cana, Brocchi; Hernanes; Rocchi, Klose
Lazio bench: Bizzarri, Radu, Cavanda, Ledesma, Sculli, Cisse, Kozak