Bojan Krkic and Fabio Simplicio are given rare starts with Aleandro Rosi in defence as Roma welcome ‘virtual leaders' Atalanta.
The 17.00 UK time kick-off at the Stadio Olimpico sees the Giallorossi looking for their first home win of the season in all competition.
Francesco Totti and Pablo Daniel Osvaldo keep their places in attack, but are joined by Spanish youngster Bojan, who has not even been a substitute for several games.
Brazilian Simplicio is a surprise pick in midfield, sending David Pizarro to the bench, while Simon Kjaer and Marco Cassetti are also dropped.
Atalanta would be the Serie A leaders were it not for their six-point penalty over a betting scandal.
Andrea Consigli recovers from a knock to start in goal, while German Denis again hopes to be inspired by Maxi Moralez and winger Ezequiel Schelotto.
Roma: 1 Lobont; 87 Rosi, 29 Burdisso, 5 Heinze, 3 Jose' Angel; 15 Pjanic, 16 De Rossi, 30 Simplicio; 14 Bojan, 10 Totti, 9 Osvaldo
Roma bench: 18 Curci, 44 Kjaer, 2 Cicinho, 77 Cassetti, 7 Pizarro, 31 Borini, 22 Borriello
Atalanta: 47 Consigli; 25 Masiello, 4 Capelli, 5 Manfredini, 13 Peluso; 7 Schelotto, 21 Cigarini, 33 Brighi, 22 Padoin; 11 Moralez; 19 Denis
Atalanta bench: 78 Frezzolini, 6 Bellini, 77 Raimondi, 26 Caserta, 10 Bonaventura, 38 Gabbiadini, 90 Tiribocchi