David Pizarro will have to prove his fitness ahead of the Rome derby after he felt a twinge in Roma training on Thursday.
The Chilean had to interrupt his work at Trigoria earlier today after feeling discomfort in his left thigh.
It's understood that club medics are not overly concerned about his complaint, but he will be closely monitored over the next 24 hours.
The 31-year-old has played in three League games under new boss Luis Enrique so far this season.
The Giallorossi are already without injured captain Francesco Totti for the Lazio tie after he admitted that he won't be fit for the clash.