Alessandro Del Piero is on the Juventus bench, as Alessandro Matri and Mirko Vucinic run out against Rodrigo Palacio's Genoa.
The Bianconeri aim to keep hold of the top spot, currently shared with Udinese, though they are without Gianluigi Buffon, Arturo Vidal and Emanuele Giaccherini.
The goalkeeper is ruled out for approximately 10 days after bruising his shoulder in training, while his teammates have thigh strains.
This means Marco Storari has his first start of the season between the posts.
Genoa haven't even picked up a point in Turin since December 1994, losing five consecutive visits in all competition.
Ze Eduardo is still out injured, while Kakha Kaladze has been given a four-match ban for his ugly scene against Lecce last week.
The former Milan defender was booked, shown a second yellow straight away for dissent and then had to be dragged away by teammates as he insulted the referee.
Giandomenico Mesto returns to the side and Kaladze is replaced by Emiliano Moretti.
Bosko Jankovic is given a rare start in support of Rodrigo Palacio, who is the current Serie A top scorer, with ex-Milan youth product Alexander Merkel.
Juventus: Storari; Chiellini, Barzagli, Bonucci, Lichtsteiner; Marchisio, Pirlo; Pepe, Matri, Vucinic, Estigarribia
Genoa: Frey; Mesto, Dainelli, Moretti, Antonelli; Rossi, Seymour, Veloso; Merkel; Jankovic, Palacio