Robinho will partner Zlatan Ibrahimovic with Alberto Aquilani facing his former club, as Milan travel to Roma.
The Rossoneri hope to continue their strong run of results when Serie A Week 10 kicks off at 17.00 UK time.
Antonio Cassano was hoping to take on his old club at the Olimpico, but is sent to the bench in favour of Robinho.
Philippe Mexes is not even in the squad, so Aquilani is the only ex-Giallorossi star in the starting XI.
Alessandro Nesta returns from injury in defence, while Gianluca Zambrotta steps in at left-back.
Luis Enrique reshuffles his Roma side yet again, bringing Nicolas Burdisso and Juan into the centre-back roles.
Miralem Pjanic recovered from a knock to start behind Pablo Daniel Osvaldo and Fabio Borini, leaving former Milan man Marco Borriello on the bench.
Francesco Totti is still out injured along with Simon Kjaer, Aleandro Rosi, Cicinho and Fabio Simplicio.
Roma: Stekelenburg; Cassetti, Burdisso, Juan, José Angel; Perrotta, De Rossi, Gago; Pjanic; Osvaldo, Borini
Roma bench: Curci, Heinze, Lamela, Bojan, Perrotta, Borriello, Greco
Milan: Abbiati; Abate, Nesta, Thiago Silva, Zambrotta; Aquilani, Van Bommel, Nocerino; Boateng; Ibrahimovic, Robinho
Milan bench: Amelia, Taiwo, Ambrosini, Bonera, Emanuelson, Yepes, Cassano