Napoli rest several stars and revamp their defence as they face a tricky test in Sicily against giant-killers Catania.
The Partenopei got back on track with their 2-0 victory over leaders Udinese on Wednesday night, but Coach Walter Mazzarri has to look ahead to the Champions League trip to Bayern Munich.
Goran Pandev, Miguel Angel Britos, Walter Gargano and Marco Donadel are on the treatment table.
Hugo Campagnaro has been left at home, with Salvatore Aronica, Marek Hamsik and Christian Maggio also rested.
This means ex-Catania hero Giuseppe Mascara acts as support for Ezequiel Lavezzi and Edinson Cavani in the 17.00 UK time kick-off.
Catania have made the Stadio Massimino a fortress and showed they tend to raise their game against the big guns.
The Elefantini have taken points off Juventus, Inter and Lazio in recent weeks. Alejandro Gomez shook off an injury to start with Gonzalo Bergessio and Adrian Ricchiuti.
On the absentee list are David Suazo, Pablo Ledesma, Ciro Capuano, Pablo Alvarez, Cristian Llama and Marco Biagianti.
Catania: Andujar; Bellusci, Legrottaglie, Spolli; Izco, Almiron, Lodi, Ricchiuti, Marchese; Bergessio, Gomez
Catania bench: Campagnolo, Potenza, Delvecchio, Lanzafame, Barrientos, Maxi Lopez, Catellani
Napoli: De Sanctis; Fernandez, Cannavaro, Fideleff; Zuniga, Santana, Inler, Dossena; Mascara, Lavezzi; Cavani
Napoli bench: Rosati, Grava, Aronica, Maggio, Dzemaili, Hamsik, Lucarelli