Djibril Cissè and Miroslav Klose lead Lazio out at the Stadio Sant'Elia against rock solid Cagliari.
The Biancocelesti must win to stay in joint second place, but the Sardinians are still unbeaten on home turf and have conceded only one goal here.
Edy Reja has to do without Stefano Mauri, Giuseppe Biava, Francelino Matuzalem and Alejandro Gonzalez.
There were rumours Tommaso Rocchi would return to the starting XI, but the front pairing of Djibril Cissè and Miroslav Klose remains intact.
Abdoullay Konko has recovered from a back problem to take the right-back role.
Cagliari have captain Daniele Conti suspended, while Davide Astori, Moustapha El Kabir and Sebastian Eriksson are injured.
Lorenzo Ariaudo steps in for Astori in defence and Albin Ekdal replaces Conti, while Brazilians Nene and Thiago Ribeiro are supported by Andrea Cossu.
Cagliari: 1 Agazzi; 14 Pisano, 21 Canini, 3 Ariaudo, 31 Agostini; 8 Biondini, 4 Nainggolan, 20 Ekdal; 7 Cossu; 18 Nenè, 19 Thiago Ribeiro
Cagliari bench: 25 Avramov, 24 Perico, 2 Gozzi, 30 Rui Sampaio, 32 Cappelini, 23 Ibarbo, 9 Larrivey
Lazio: 83 Marchetti; 29 Konko, 21 Diakitè, 3 Dias, 26 Radu; 32 Brocchi, 24 Ledesma, 19 Lulic; 8 Hernanes; 99 Cisse, 25 Klose
Lazio bench: 1 Bizzarri, 5 Scaloni, 33 Stankevicius, 27 Cana, 18 Kozak, 7 Sculli, 9 Rocchi