Lazio hand the reins to Miroslav Klose, Tommaso Rocchi and Giuseppe Sculli in a decisive Europa League clash with FC Zurich.
The Biancocelesti have only two points from their first three games in this group, but are still in the running for the second qualifying spot.
Hernanes is only fit for the bench due to a swollen ankle, while Djibril Cissè is rested, so veteran captain Rocchi partners Klose in attack.
Sculli and Senad Lulic spread out wide to support the forwards and Andre Dias has shaken off a knock to start in defence.
Zurich and Vaslui also have two points, as Group D leaders Sporting have already qualified on nine.
The Swiss outfit held Lazio to a 1-1 draw when they met in Matchday 3 and hope to pick up another positive result at the Olimpico, kick-off at 18.00 UK time.
Lazio: Marchetti; Zauri, Diakitè, Dias, Radu; Lulic, Cana, Ledesma, Sculli; Rocchi, Klose
Lazio bench: Bizzarri, Konko, Crescenzi, Hernanes, Brocchi, Kozak, Cissè
Zurich: Leoni; P Koch, Beda, Jorge Teixeira, Rodriguez; Mehmedi, Aegerter, Zouaghi, Djuric; Chikhaoui, Alphonse
Zurich bench: Guatelli, R Koch, Magnin, Buff, Barmettler, Schonbachler, Chermiti