Milan revamp their attack with Urby Emanuelson as trequartista behind Robinho and Zlatan Ibrahimovic against Catania.
The Rossoneri aim to continue their climb towards the top of Serie A with this afternoon’s game at San Siro.
Antonio Cassano will be watching from home, having been released from hospital last night after surgery to correct a congenital heart defect.
There are many banners around the stadium wishing FantAntonio well and even Real Madrid ran out against Osasuna this morning wearing Cassano’s old number 19 jersey.
Alessandro Nesta, Gennaro Gattuso, Alexandre Pato, Philippe Mexes, Mathieu Flamini and suspended duo Kevin-Prince Boateng and Antonio Nocerino are also out of this match.
Emanuelson is thrown in as a makeshift trequartista behind the strikers, while Clarence Seedorf returns from injury to bolster the midfield.
Daniele Bonera steps in at centre-back to replace Nesta.
Catania are fresh from giant-killing exploits to beat Inter and Napoli, while they have done well recently at San Siro.
Ex-Milan defender Nicola Legrottaglie, who only managed a couple of appearances for the club last season, starts in the back four with Davide Lanzafame as a surprise pick at right-back.
On the injury list are Mariano Izco, Pablo Alvarez, Cristian Llama and David Suazo.
Milan: Abbiati; Abate, Bonera, Thiago Silva, Zambrotta; Aquilani, Ambrosini, Seedorf; Emanuelson; Robinho, Ibrahimovic
Catania: Andujar; Lanzafame, Bellusci, Legrottaglie, Spolli; Marchese, Almiron, Lodi, Ricchiuti; Gomez, Bergessio