Juventus have Alessandro Matri and Mirko Vucinic leading the way against Fabrizio Miccoli’s reshuffled Palermo.
The Bianconeri could go top of the table despite having a game in hand, if Udinese fail to conquer Parma this afternoon.
With injury problems now behind him, Antonio Conte declared his choices would now be purely tactical and technical.
Vucinic and Matri get the nod in attack with Simone Pepe and Arturo Vidal, while Giorgio Chiellini moves to left-back again.
Palermo have won their last three visits to Turin, but have a dismal away record this season.
There are also injury worries, as Mauricio Pinilla and Abel Hernandez are out, meaning Miccoli is the only available striker.
He has to take the unusual centre-forward role against his former club, backed by Josip Ilicic and Nicolas Bertolo in a double-trequartista system.
Juventus: 1 Buffon, 26 Lichtsteiner, 19 Bonucci, 15 Barzagli, 3 Chiellini; 8 Marchisio, 21 Pirlo; 7 Pepe, 22 Vidal, 14 Vucinic; 32 Matri
Juventus bench: 30 Storari, 11 De Ceglie, 5 Pazienza, 17 Elia, 24 Giaccherini, 18 Quagliarella, 10 Del Piero
Palermo: 33 Tzorvas, 31 Pisano, 3 Silvestre, 4 Cetto, 42 Balzaretti; 8 Migliaccio, 21 Bacinovic, 5 Barreto; 14 Bertolo, 27 Ilicic; 10 Miccoli
Palermo bench: 99 Benussi, 2 Mantovani, 6 Munoz, 7 Della Rocca, 20 Acquah, 16 Zahavi, 26 Lores