Inter have Ricky Alvarez, Giampaolo Pazzini and Diego Milito together against Antonio Di Natale’s Udinese.
The Nerazzurri have revived their fortunes in recent weeks, but welcome the high-flying Friulani to San Siro.
Diego Forlan, Wesley Sneijder, Lucio, Douglas Maicon, Sulley Muntari and Emiliano Viviano are out of action for the home side.
Mauro Zarate is rested in favour of Pazzini and Milito, with support from Alvarez, while Under-21 international Marco Davide Faraoni is given a surprise midfield start.
Udinese were held to a 0-0 draw at Rennes in the Europa League midweek and are third in Serie A.
Almen Abdi was added to the injury list with Maurizio Domizzi, Andrea Coda and Paulo Vitor Barreto.
This means Gabriel Torje is chosen for the trequartista role behind Antonio Di Natale.
Inter: 1 Julio Cesar; 4 Zanetti, 23 Ranocchia, 25 Samuel, 26 Chivu; 37 Faraoni, 8 Thiago Motta, 19 Cambiasso, 11 Alvarez; 7 Pazzini, 22 Milito
Inter bench: 12 Castellazzi, 2 Cordoba, 5 Stankovic, 18 Poli, 28 Zarate, 30 Castaignos,55 Nagatomo
Udinese: 1 Handanovic; 17 Benatia, 5 Danilo, 32 Ferronetti; 8 Basta, 3 Isla, 66 Pinzi, 20 Asamoah, 27 Armero; 25 Torje; 10 Di Natale
Udinese bench: 21 Padelli, 7 Badu, 24 Ekstrand, 26 Pasquale, 30 Doubai, 31 Fabbrini, 83 Floro Flores