Lazio will play Atletico Madrid in the last 32 of the Europa League, while Udinese have been paired with PAOK Salonika.
There was a danger that the Italian duo could be faced with tests against the likes of Manchester United and Manchester City, but the draw was kinder than that.
The capital outfit will still have a tough game against their Spanish counterparts, but the Stadio Friuli outfit will fancy their chances against Greek opposition.
Should the two teams progress then Lazio will play either Braga or Besiktas, while Alkmaar or Anderlecht will be waiting for the side from Udine.
The two-legged last 32 ties will be played on February 16 and 23.
Last 32 draw
FC Porto v Manchester City FC
AFC Ajax v Manchester United FC
FC Lokomotiv Moskva v Athletic Club
FC Salzburg v FC Metalist Kharkiv
Stoke City FC v Valencia CF
FC Rubin Kazan v Olympiacos FC
AZ Alkmaar v RSC Anderlecht
S.S. Lazio v Club Atlético de Madrid
FC Steaua Bucureşti v FC Twente
FC Viktoria Plzeň v FC Schalke 04
Wisła Kraków v R. Standard de Liège
SC Braga v Beşiktaş JK
Udinese v PAOK FC
Trabzonspor AŞ v PSV Eindhoven
Hannover 96 v Club Brugge KV
Legia Warszawa v Sporting Clube de Portugal
Last 16 draw
Salzburg/Metalist v Rubin/Olympiacos
Legia/Sporting v Porto/Manchester City
Steaua/Twente v Plzeň/Schalke
Wisła/Standard v Hannover/Brugge
Stoke/Valencia v Trabzonspor/PSV
Alkmaar/Anderlecht v Udinese/PAOK
Lazio/Atlético v Braga/Beşiktaş
Porto/Manchester United v Lokomotiv/Athletic