Lazio and Udinese go head-to-head for second place in a revival of last season’s battle for Champions League places with some surprising changes.
The Friulani had the upper hand last year, securing fourth place on goal difference, and are currently two points in front.
The Biancocelesti have a length injury list that includes Federico Marchetti, Stefano Mauri, Cristian Brocchi, Abdoullay Konko, Simone Del Nero, Stephen Makinwa and Emanuele Berardi.
Djibril Cissè is dropped in favour of veteran Tommaso Rocchi, who partners Miroslav Klose, while Andre Dias returns to the re-jigged three-man defence.
Udinese are missing Emmanuel Badu, Andrea Coda and Paulo Vitor Barreto, while Francesco Guidolin has to balance a schedule of three games in six days.
This is why Antonio Di Natale and Pablo Armero are on the bench to begin with, giving Gabriel Torje and Antonio Floro Flores the chance to start.
Lazio: 1 Bizzarri; 21 Diakitè, 3 Dias, 26 Radu; 39 Cavanda, 15 Gonzalez, 24 Ledesma, 19 Lulic, 7 Sculli; 25 Klose, 9 Rocchi
Lazio bench: 84 Carrizo, 5 Scaloni, 33 Stankevicius, 27 Cana, 18 Kozak, 8 Hernanes, 99 Cissè
Udinese: 1 Handanovic; 17 Benatia, 5 Danilo, 32 Ferronetti; 8 Basta, 3 Isla, 66 Pinzi, 20 Asamoah, 26 Pasquale; 83 Floro Flores; 25 Torje
Udinese bench: 21 Padelli, 11 Domizzi, 27 Armero, Sissoko, 23 Abdi, 31 Fabbrini, 10 Di Natale
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!