Palermo have thrown new buy Franco Vazquez into the starting XI as they welcome a reshuffled Napoli in the evening kick-off.
Serie A Week 17 concludes at 19.45 UK time when these two teams take to the field at the Stadio Barbera.
Josip Ilicic sits out a ban, joining the injured Abel Hernandez, Eran Zahavi and Eros Pisano, while Mauricio Pinilla is only fit for the bench.
This means that January signing Vazquez is thrown in at the deep end, going straight into the starting line-up with Fabrizio Miccoli and Igor Budan.
The game also represents the home debut of Coach Bortolo Mutti, who only had a 2-2 draw away to Novara in charge before Christmas.
Napoli are without Ezequiel Lavezzi due to a thigh strain, so Goran Pandev steps in to complete the trident with Marek Hamsik and Edinson Cavani.
Palermo: 99 Benussi; 6 Munoz, 3 Silvestre, 4 Cetto, 42 Balzaretti; 8 Migliaccio, 7 Della Rocca, 5 Barreto; 17 Vazquez; 19 Budan, 10 Miccoli
Palermo bench: 33 Tzorvas, 2 Mantovani, 20 Acquah, 21 Bacinovic, 90 Alvarez, 24 Mehmeti, 51 Pinilla
Napoli: 1 De Sanctis, 14 Campagnaro, 28 Cannavaro, 6 Aronica; 11 Maggio, 88 Inler, 23 Gargano, 8 Dossena; 17 Hamsik, 29 Pandev; 7 Cavani
Napoli bench: 83 Rosati, 21 Fernandez, 2 Grava, 20 Dzemaili, 18 Zuniga, 9 Mascara, 32 Chavez
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!