Emiliano Alfaro was set to receive his Lazio debut against Milan on Thursday, but misses out due to a calf problem.
The Uruguayan striker completed his transfer from Liverpool Montevideo earlier this month and has been on the bench in Serie A without actually playing.
He was expected to feature in the Coppa Italia quarter-final against Milan, but is not even in the squad named by Coach Edy Reja this evening.
That is because Alfaro picked up a left calf problem during training and will not be risked.
Ex-Milan midfielder Christian Brocchi also misses out after a knock to his left foot.
Lazio squad:Bizzarri, Carrizo, Marchetti; Biava, Diakitè, Dias, Garrido, Konko, Lulic, Radu, Scaloni, Stankevicius, Zauri; Del Nero, Gonzalez, Hernanes, Ledesma, Matuzalem, Zampa; Cissè, Klose, Rocchi