Napoli have rotated their squad for the trip to Genoa, creating a new trident of Marek Hamsik, Goran Pandev and Ezequiel Lavezzi.
The Partenopei feared fatigue after their midweek Coppa Italia quarter-final victory over Inter, so Walter Mazzarri has rested Edinson Cavani and Gokhan Inler.
Miguel Angel Britos and Blerim Dzemaili are given rare starts, while Pandev completes the trident with a fit-again Lavezzi.
Genoa want revenge in this fixture after they were beaten 6-1 at the San Paolo in December, a result that saw Coach Alberto Malesani sacked.
New signings Alberto Gilardino and Giuseppe Sculli – as well as Coach Pasquale Marino – weren’t at Genoa that day, but are present here.
The Grifone have to do without Marco Rossi, Kevin Constant, Luca Antonelli, Dario Dainelli, Miguel Veloso and Cesare Bovo.
Genoa: Frey, Granqvist, Kaladze, Moretti, Mesto, Biondini, Jankovic, Kucka, Sculli, Palacio, Gilardino
Genoa bench: Lupatelli, Sampirisi, Ze Eduardo, Seymour, Birsa, Jorquera, Pratto
Napoli: De Sanctis, Campagnaro, Cannavaro, Britos, Zuniga, Dzemaili, Gargano, Dossena, Hamsik, Lavezzi, Pandev
Napoli bench: Rosati, Grava, Fernandez, Inler, Vargas, Cavani
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!