Milan have Maxi Lopez on the bench, but start with Urby Emanuelson, while Cagliari give Mauricio Pinilla his debut.
Serie A Week 20 is concluded at 19.45 UK time at San Siro when the Rossoneri welcome Massimiliano Allegri’s former club.
A growing injury crisis has ruled out Thiago Silva, Luca Antonini, Kevin-Prince Boateng, Alexandre Pato, Alberto Aquilani, Alexander Merkel, Gennaro Gattuso, Mario Yepes, Antonio Cassano and Mathieu Flamini.
Maxi Lopez joined from Catania on Friday evening and is on the bench, as Emanuelson starts with Zlatan Ibrahimovic and Robinho, but it remains to be seen whether he or Clarence Seedorf have the trequartista role. Lopez has inherited the Number 21 jersey worn for many years by Andrea Pirlo.
Djamel Mesbah is given the nod in defence after a fine performance in the Coppa Italia against Lazio midweek.
Cagliari are without Nene, Sebastian Eriksson and Lorenzo Ariaudo, while they haven’t picked up a single point here for 12 years.
The Sardinians also picked up a new signing this week, taking striker Pinilla from Palermo, who is thrown straight into the starting XI.
Milan: Abbiati; Abate, Nesta, Mexes, Mesbah; Emanuelson, Van Bommel, Nocerino; Seedorf; Ibrahimovic, Robinho
Milan bench: Amelia, El Shaarawy, Inzaghi, Zambrotta, Maxi Lopez, Ambrosini, Bonera
Cagliari: Agazzi; Pisano, Canini, Astori, Agostini; Dessena, Ekdal, Nainggolan; Cossu; Ibarbo, Pinilla
Cagliari bench: Avramov, Gozzi, Conti, Larrivey, El Kabir, Thiago Ribeiro, Perico