Roma have given the nod to Jose Angel and Fabio Borini, while Cagliari have ex-Giallorossi star Daniele Conti.
Luis Enrique lost his Serie A debut against Cagliari, falling 2-1 at the Olimpico in September with Conti on target.
The son of Roma legend Bruno Conti is in the starting XI after his injury problems, while Davide Astori shook off an injury to feature as well.
Rui Sampaio, Nene and Sebastian Eriksson are out of action, but January signing Mauricio Pinilla partners Victor Ibarbo.
The Giallorossi are without Daniele De Rossi, Pablo Daniel Osvaldo, Nicolas Burdisso and Marco Cassetti.
Erik Lamela and Francesco Totti are, as usual, in the trident and this time joined by Under-21 international Borini.
Jose Angel returns at left-back for Rodrigo Taddei.
Cagliari: 1 Agazzi; 14 Pisano, 21 Canini, 13 Astori, 31 Agostini; 27 Dessena, 5 Conti, 4 Nainggolan; 7 Cossu; 51 Pinilla, 23 Ibarbo
Cagliari bench: 25 Avramov, 2 Gozzi, 24 Perico, 20 Ekdal, 9 Larrivey,19 Thiago Ribeiro, 10 El Kabir
Roma: 24 Stekelenburg; 87 Rosi, 44 Kjaer, 4 Juan, 3 Jose Angel; 15 Pjanic , 19 Gago, 30 Simplicio; 10 Totti, 8 Lamela, 31 Borini
Roma bench: 18 Curci, 5 Heinze, 11 Taddei, 20 Perrotta, 14 Bojan, 23 Greco, 92 Viviani