Diego Milito, Giampaolo Pazzini and Angelo Palombo face Francesco Totti, Erik Lamela and Daniele De Rossi in the big Roma-Inter clash.
This game was originally set to kick off on Saturday evening, but the heavy snow that saw the Capital ground to a halt prompted a postponement.
Claudio Ranieri returns to the Olimpico for the first time as an opponent since he resigned from his hometown club last season.
Wesley Sneijder, Ricky Alvarez, Dejan Stankovic, Diego Forlan and new buy Fredy Guarin are unavailable, so Inter go back to the 4-4-2 system topped by Milito and Pazzini.
January signing Palombo starts in midfield with Joel Obi, while ex-Roma star Walter Samuel partners Lucio in central defence.
Roma miss Marco Cassetti, Pablo Daniel Osvaldo, Simone Perrotta and Nicolas Burdisso, but Daniele De Rossi is fit for the starting XI.
De Rossi has been out for the better part of a month and was expected to miss this game too, but starts with Fernando Gago and Miralem Pjanic in midfield.
Rodrigo Taddei and Jose Angel are the full-backs this time with Gabriel Heinze rather than Simon Kjaer in the centre.
Fabio Borini is picked ahead of Bojan Krkic to complete the trident attack.
Roma: 24 Stekelenburg; 11 Taddei, 5 Heinze, 4 Juan, 3 Josè Angel; 19 Gago, 16 De Rossi, 15 Pjanic; 10 Totti, 8 Lamela, 31 Borini
Roma bench: 1 Lobont, 44 Kjaer, 87 Rosi, Piscitella 23 Greco, 30 Simplicio, 14 Bojan
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 25 Samuel, 55 Nagatomo; 4 Zanetti, 17 Palombo, 19 Cambiasso, 20 Obi; 7 Pazzini, 22 Milito
Inter bench: 12 Castellazzi, 2 Cordoba, 23 Ranocchia, 26 Chivu, 37 Faraoni, 18 Poli, 28 Zarate, 30 Castaignos
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!