Juventus give Martin Caceres and Simone Padoin their first starts against Milan’s Zlatan Ibrahimovic and Stephan El Shaarawy in the Coppa Italia semi-final.
The two sides battling for the Scudetto also go head-to-head in the first leg of the Coppa clash, kick-off 19.45 UK time at San Siro.
The Rossoneri are without a host of star names, but can count on Ibrahimovic, who will miss the Serie A clash with Juventus due to a three-match ban.
The Disciplinary Commission separates the two competitions, so Ibra is still available in the Coppa Italia.
He is partnered by El Shaarawy with support from Clarence Seedorf, while Daniele Bonera gets a rare start in defence.
Juventus rotate their squad with Marco Storari stepping in between the posts, while Alessandro Del Piero starts alongside former Milan striker Borriello.
January signings Caceres and Padoin are given their first starts, as Giorgio Chiellini moves to left-back.
Milan: Amelia, Bonera, Mexes, Thiago Silva, Antonini, Emanuelson, Van Bommel, Ambrosini, Seedorf, Ibrahimovic, El Shaarawy
Milan bench: Roma, Zambrotta, Mesbah, Cristante, Inzaghi, Robinho, Maxi Lopez
Juventus: Storari; Caceres, Bonucci, Barzagli, Chiellini; Giaccherini, Pirlo, Padoin, Estigarribia; Del Piero, Borriello
Juventus bench: Manninger, Lichtsteiner, Marrone, Marchisio, Elia, Quagliarella, Vucinic
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!