Inter have Wesley Sneijder and Ricky Alvarez with Diego Milito and the returning Dejan Stankovic, as they welcome bottom of the table Novara.
The Nerazzurri need to get back on track after one point from their last two games, which included a 4-0 hammering at Roma.
Novara are in considerably worse shape, propping up the table and with only two victories all season – one of them 3-1 against Inter in September, which cost Gian Piero Gasperini his job.
Douglas Maicon sits out a ban, while Walter Samuel and Fredy Guarin are injured.
Sneijder returns and it looks as if the system changes to a 4-3-2-1 with Alvarez in a joint trequartista role behind Milito, while Stankovic makes his first appearance since the 1-0 win away to Cesena on December 18.
Novara are without Francesco Marianini, Taka Morimoto and Carlalberto Ludi.
Andrea Caracciolo leads the attack, but Giuseppe Mascara has pulled out at the last minute, so is not even on the bench.
Instead, former Cagliari man Jeda is the support, as Novara seem to switch to a 3-5-2 approach.
Inter: Julio Cesar; Zanetti, Lucio, Cordoba, Chivu; Poli, Stankovic, Cambiasso; Alvarez, Sneijder; Milito
Inter bench: Castellazzi, Ranocchia, Nagatomo, Palombo, Obi, Pazzini, Forlan
Novara: Ujkani; Lisuzzo, Centurioni, Garcia; Dellafiore, Porcari, Radovanovic, Rigoni, Gemiti; Jeda, Caracciolo
Novara bench: Fontana, Rubino, Gabriel, Morganella, Pesce, Paci, Rinaudo