Udinese rely on Antonio Floro Flores and Gabriel Torje, as Cagliari bring a South American attack to the Stadio Friuli.
The Friulani are in crisis after their defeat to Milan and disappointing 0-0 draw with PAOK in the Europa League.
Mauricio Isla is out for the next three months, while top scorer Antonio Di Natale suffered a microfracture to his foot.
He is joined on the treatment table by Emmanuel Badu and Giampiero Pinzi.
Therefore, Antonio Floro Flores partners Romanian youngster Gabriel Torje in a 3-5-1-1 system.
Cagliari also have issues to contend with, as Daniele Conti is suspended with Moustafa El Kabir, Nene, Rui Sampaio and Sebastian Eriksson injured.
They go on the attack in Udine, though, fielding Thiago Ribeiro with Mauricio Pinilla and the barely fit Andrea Cossu
Udinese:Handanovic; Benatia, Danilo, Domizzi; Basta, Pazienza, Abdi, Fernandes, Armero; Torje; Floro Flores
Udinese bench: Padelli, Ferronetti, Coda, Pasquale, Fanchone, Battocchio, Fabbrini
Cagliari:Agazzi; Pisano, Canini, Astori, Agostini; Dessena, Ekdal, Nainngolan; Thiago Ribeiro, Pinilla, Cossu
Cagliari bench: Avramov, Ariaudo, Perico, Gozzi, Ibarbo, Cepellini, Larrivey