Inter have a 4-4-1-1 system in Marseille this evening with Mauro Zarate out wide and Wesley Sneijder behind Diego Forlan.
The Nerazzurri are in crisis after losing five of their last six games in all competition and failing to score in all but the 4-4 draw with Palermo.
The pressure is on Claudio Ranieri and a big defeat in the first leg of this Champions League Round of 16 tie could see him sacked.
Walter Samuel makes his comeback, while Forlan is finally available after he was cup-tied for the group phase of the competition.
Forlan has been picked instead of Diego Milito as a partner for Sneijder in the new 4-4-1-1 line-up.
The biggest surprise is Zarate out wide on the left flank.
Olympique Marseille are coached by former Juventus boss Didier Deschamps, who must do without Loic Remy and Stephane Mbia, while Andre-Pierre Gignac is only fit for the bench.
Alou Diarra picked up a toe injury at the weekend, but is fit to start, as Brandao leads the way.
Marseille: Mandanda; Azpilicueta, Diawara, N'Koulou, Morel; Diarra, Cheyrou; Amalfitano, Valbuena, A Ayew; Brandao
Marseille bench: Bracigliano, Fanni, Kaboré, Sabo, Traoré, J Ayew, Gignac
Inter: Julio Cesar; Maicon, Lucio, Samuel, Chivu; Zanetti, Stankovic, Cambiasso, Zarate; Sneijder; Forlan
Inter bench: Castellazzi, Ranocchia, Nagatomo, Poli, Obi, Pazzini, Milito
Ref: Cuneyt Cakir (Tur)