Roma have replaced Francesco Totti and Daniele De Rossi for their trip to Atalanta with Fabio Borini, Daniel Pablo Osvaldo and Marquinho.
The Giallorossi must do without their talismanic captain, who sits out a one-match ban, plus the long-term injury absentee Nicolas Andre Burdisso.
In a surprise move, Luis Enrique has also dropped Daniele De Rossi reportedly due to disciplinary matters, giving Brazilian January signing Marquinho his first start.
Erik Lamela joins Borini and Osvaldo in attack, while Juan partners Gabriel Heinze in defence.
Rodrigo Taddei and Aleandro Rosi are the full-backs this time round.
Atalanta are without Adriano Ferreira Pinto, Daniele Capelli and Carlos Carmona.
Atalanta: Consigli; Lucchini, Stendardo, Manfredini, Peluso; Carrozza, Cigarini, Brighi,, Moralez; Marilungo, Denis
Atalanta bench: Frezzolini, Bellini, Cazzola, Bonaventura, Schelotto, Gabbiadini, Tiribocchi
Roma: Stekelenburg; Rosi, Heinze, Juan, Taddei; Pjanic, Gago, Marquinho; Osvaldo, Lamela, Borini
Roma bench: Lobont, Cassetti, José Angel, Perrotta, Greco, Piscitella, Bojan