Roma have a risky set-up with Rodrigo Taddei and Jose Angel in defence against Lazio’s strike force of Miroslav Klose and Hernanes.
The Derby della Capitale takes place at a packed Stadio Olimpico at 14.00 UK time this afternoon.
The Giallorossi are still smarting from their 4-1 thrashing away to Atalanta, which also cost them bans for Daniel Pablo Osvaldo, Fernando Gago and Marco Cassetti.
Francesco Totti returns from his suspension, while Daniele De Rossi is back in the side after he was punished for turning up late to a team meeting.
Luis Enrique takes big risks in defence, where Taddei and Jose Angel represent very attacking full-backs.
Lazio have a huge injury list that rules out Senad Lulic, Stefan Radu, Abdoullay Konko, Luciano Zauri, Tommaso Rocchi, Cristian Brocchi, Marius Stankevicius and Lorik Cana.
Klose leads the attack with support from Alejandro Gonzalez, Stefano Mauri and Hernanes.
The defence is also reshuffled with Lionel Scaloni and Javier Garrido.
Roma: Stekelenburg; Taddei, Juan, Heinze, Jose Angel; Simplicio, De Rossi, Pjanic; Borini, Totti, Lamela
Roma bench:Lobont, Rosi, Kjaer, Marquinho, Greco, Bojan, Piscitella
Lazio: Marchetti; Scaloni, Biava, Dias, Garrido; Ledesma, Matuzalem; Gonzalez, Hernanes, Mauri; Klose
Lazio bench: Bizzarri, Diakitè, Sbraga, Candreva, Zampa, Alfaro, Kozak