Juventus have Arturo Vidal playing centre-back as Genoa welcome Alberto Gilardino back from an injury lay-off.
The Bianconeri risk falling off the title pace after five draws from their last six rounds. Antonio Conte is in the stands due to a touchline ban, while the defence is completely revamped.
Giorgio Chiellini and Andrea Barzagli are injured along with the suspended Leonardo Bonucci, so Vidal acts as makeshift centre-back.
Mirko Vucinic keeps his spot in attack and is joined by Alessandro Matri and Simone Pepe.
Genoa are missing Cesare Bovo, Andreas Granqvist and Luca Antonelli, but welcome back Gilardino from an injury lay-off.
Genoa: Frey; Rossi, Carvalho, Kaladze, Moretti; Jankovic, Kucka, Biondini, Sculli; Gilardino, Palacio
Juventus: Buffon; Lichtsteiner, Caceres, Vidal, De Ceglie; Giaccherini, Pirlo, Marchisio; Pepe, Matri, Vucinic
Juventus bench: Storari, Marrone, Padoin, Elia, Del Piero, Quagliarella, Borriello