Clarence Seedorf steps in to support Alexandre Pato and Zlatan Ibrahimovic as leaders Milan travel to Lecce.
Antonio Cassano is on the bench once again, but will come on later against the rivals of his hometown club Bari.
Coach Max Allegri had to do without the injured Christian Abbiati, Kevin-Prince Boateng, Gianluca Zambrotta, Andrea Pirlo and Pippo Inzaghi.
Massimo Ambrosini returns to the midfield after his ban alongside Mathieu Flamini, but Robinho is suffering from flu and therefore rested in favour of Seedorf.
Lecce are fresh from their shock 2-1 victory away to Lazio and hope for another famous scalp.
David Di Michele and Nelson Jeda form the front two for the Salentini.
Lecce: Rosati; Tomovic, Gustavo, Fabiano, Mesbah; Vives; Munari, Bertolacci, Grossmuller; Jeda, Di Michele
Milan: Amelia; Abate, Nesta, Thiago Silva, Bonera; Gattuso, Ambrosini, Flamini; Seedorf; Pato, Ibrahimovic
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more