Milan give Antonio Cassano his first Serie A start against Cesena alongside Zlatan Ibrahimovic and Robinho.
The Serie A leaders welcome the Sea Horses to San Siro for the Sunday evening kick-off.
Cassano impressed in his full debut on Thursday, a 3-0 victory over Bari for the Coppa Italia, and is again chosen ahead of Alexandre Pato.
Coach Massimiliano Allegri must do without Andrea Pirlo, Clarence Seedorf, Kevin-Prince Boateng, Gianluca Zambrotta, Marco Amelia, Marek Jankulovski and Pippo Inzaghi.
Christian Abbiati does return to take the gloves with Alexander Merkel in midfield.
Cesena were at San Siro on Wednesday in the rescheduled Week 16 match and gave Inter quite a scare, only losing 3-2.
Emanuele Giaccherini was very harshly sent off in that game and is suspended, while Luis Jimenez, Ivan Fatic and Maurizio Lauro have come down with a flu virus.
It means Ezequiel Schelotto gets a rare start in the trident attack with Igor Budan and Dominique Malonga.
Milan: Abbiati; Abate, Nesta, Thiago Silva, Antonini; Gattuso, Ambrosini, Merkel; Robinho; Cassano, Ibrahimovic
Cesena: Antonioli; Ceccarelli, Pellegrino, Von Bergen, Dellafiore; Caserta, Colucci, Parolo; Schelotto, Budan, Malonga