Inter are in the midst of an injury crisis and switch to a 4-4-2 system with Goran Pandev and Coutinho out wide against Alessandro Diamanti's Brescia.
San Siro hosts the evening kick-off as the Rondinelle pay visit to the reigning Italian champions.
The Nerazzurri are still smarting from their 3-1 Champions League defeat to Tottenham.
Injury problems remain with Sulley Muntari, Dejan Stankovic, MacDonald Mariga, Thiago Motta, David Suazo, Esteban Cambiasso and Julio Cesar out of action.
To help cover the midfield more, Rafa Benitez has moved them into a 4-4-2 system with Pandev and Coutinho on the wings.
It puts the versatile Javier Zanetti in a central midfield position along with Wesley Sneijder behind Diego Milito and Samuel Eto'o.
Brescia have to do without Hugo Mareco and goalkeeper Matteo Sereni, but welcome back Diamanti after his three-match ban for insulting the referee.
Inter: 12 Castellazzi; 13 Maicon, 6 Lucio, 25 Samuel, 26 Chivu; 27 Pandev, 4 Zanetti, 10 Sneijder, 29 Coutinho; 22 Milito, 9 Eto'o
Inter bench: 21 Orlandoni, 2 Cordoba, 20 Obi, 23 Materazzi, 39 Santon, 40 Nwankwo, 88 Biabiany
Brescia: 1 Arcari; 5 Zebina, 9 Caracciolo, 11 Cordova, 17 Baiocco,23 Dallamano, 26 Martinez, 28 Berardi, 32 Diamanti, 33 Kone, 56 Hetemaj
Brescia bench: 12 Leali, 6 Bega, 7 Eder, 8 Vass, 15 Zambelli, 18 Possanzini, 19 Budel