Adrian Mutu and Artur Boruc lead Fiorentina out against Chievo, who are missing Sergio Pellissier.
The lunch-time kick-off at 11.30 UK time is at the Stadio Artemio Franchi, but both sides have numerous injury woes.
Viola stars Sebastien Frey and Riccardo Montolivo will undergo surgery next week on a knee and ankle problem respectively.
They join Stevan Jovetic, Gaetano D'Agostino, Cristiano Zanetti, Dias Felipe and Khouma Babacar on the treatment table, while Cesare Natali is suspended.
It gives Mario Bolatti a very rare midfield start, while Mutu again partners Alberto Gilardino after the end of his doping ban last week.
The big change is Boruc in goal, as the former Celtic hero finally gets his chance to shine in Serie A.
Chievo are forced to do without their top striker Pellissier along with Gennaro Sardo and Luciano. Gelson Fernandes sits out a ban, so Davide Moscardelli has won the race to support Cyril Thereau up front.
It is a pity goalkeeper Frey was unable to start, as his younger brother Nicolas plays for Chievo.
Fiorentina: Boruc; Comotto, Gamberini, Kroldrup, Pasqual; Bolatti, Donadel; Marchionni, Mutu, Santana; Gilardino
Fiorentina bench: Avramov, Vargas, Papa Waigo, Ljajic, Cerci, De Silvestri
Chievo: Sorrentino, N Frey, Andreolli, Cesar, Mantovani, Guana, Bentivoglio, Constant, Marcolini, Moscardelli, Thereau
Chievo bench: Squizzi, Mandelli, Granoche, Jokic, Rigoni, Bogliacino, De Paula