It's an exciting battle at San Siro, as Antonio Cassano returns with Zlatan Ibrahimovic to face Parma's trident of Sebastian Giovinco, Amauri and Hernan Crespo.
The 17.00 UK time kick-off sees leaders Milan aim to get back on track after a series of stalemates.
Alessandro Nesta makes his comeback from a dislocated shoulder, while Clarence Seedorf also returns from an injury lay-off.
Cassano is chosen to partner Ibra following his performance for Italy on Wednesday, but also allows Robinho and Alexandre Pato to rest ahead of the Champions League.
Andrea Pirlo and Massimo Ambrosini have both been ruled out for six weeks, so Alexander Merkel and Mark Van Bommel take over in midfield.
Parma are pulling out all the stops with an audacious starting XI at San Siro, pitting Crespo against his former club.
He is joined by Amauri, who scored a sensational overhead kick last week, and Giovinco fresh from his senior Italy debut against Germany.
Stefano Morrone sits out a ban, while Toni Calvo and Rafael Marques are sidelined.
Milan: Abbiati; Oddo, Nesta, Thiago Silva, Antonini; Gattuso, Van Bommel, Merkel; Seedorf; Ibrahimovic, Cassano
Parma: Mirante; Gobbi, Lucarelli, Paci, Zaccardo; Valiani, Dzemaili, Candreva; Giovinco, Amauri, Crespo