Marco Borriello, Mirko Vucinic and Fabio Simplicio take on Marek Hamsik, Ezequiel Lavezzi and Edinson Cavani in tonight's Roma-Napoli.
The Derby del Sole kicks off at 19.45 UK time and represents a real Scudetto showdown as well as a battle for Champions League spots.
The Giallorossi make some changes ahead of the European encounter with Shakhtar Donetsk, resting Francesco Totti and Jeremy Menez.
Instead, Claudio Ranieri has picked Vucinic with Borriello and support in midfield from Simone Perrotta and Simplicio.
The defence is reshuffled due to bans for Philippe Mexes and Nicolas Burdisso, so right-back Marco Cassetti is re-routed into the centre, making way for Aleandro Rosi.
Napoli are missing Gianluca Grava and Luigi Vitale, but the rest of the squad is available for Coach Walter Mazzarri.
Hamsik and Lavezzi take their usual places supporting Capocannoniere Cavani.
Roma: Julio Sergio; Rosi, Cassetti, Juan, Riise; Taddei, De Rossi, Perrotta, Simplicio; Borriello, Vucinic
Roma bench: Doni, Castellini, Loria, Brighi, Greco, Totti, Menez
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica, Maggio, Gargano, Pazienza, Dossena, Hamsik, Lavezzi, Cavani
Napoli bench: Iezzo, Santacroce, Cribari, Zuniga, Yebda, Sosa, Mascara
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!