Luca Toni, Milos Krasic and Alessandro Matri take on Samuel Eto'o, Wesley Sneijder and Giampaolo Pazzini in tonight's Derby d'Italia.
Juventus welcome Inter to the Stadio Olimpico in Turin from 19.45 UK time for one of the most heated rivalries in Italian football.
Alessandro Del Piero is left on the bench for this huge match, as January signings Matri and Toni start together for the first time.
Gigi Del Neri has to do without Leandro Rinaudo, Paolo De Ceglie, Fabio Quagliarella and Armand Traoré, while Simone Pepe, Vincenzo Iaquinta and Claudio Marchisio are not 100 per cent fit.
Marchisio starts anyway on the left side of midfield with Alberto Aquilani in the middle. Giorgio Chiellini is again placed at left-back, so Danish 18-year-old Frederik Sorensen is given the task of dealing with Eto'o.
Leonardo hopes to continue his remarkable record at the helm of Inter and to consolidate third place.
Diego Milito, Dejan Stankovic, MacDonald Mariga, Lucio, Walter Samuel and the suspended Cristian Chivu are unavailable.
Sneijder again starts in the trequartista role behind strikers Eto'o and Pazzini, while January reinforcements Houssine Kharja and Andrea Ranocchia also line up.
Inter have not won this Serie A fixture since April 2005, when Julio Ricardo Cruz scored the only goal. That was followed by two home wins and as many draws, both 1-1.
Juventus: 1 Buffon; 43 Sorensen, 15 Barzagli, 19 Bonucci, 3 Chiellini; 27 Krasic, 4 Melo, 14 Aquilani, 8 Marchisio; 20 Toni 32 Matri
Juventus bench: 30 Storari, 5 Sissoko, 9 Iaquinta, 10 Del Piero, 21 Grygera, 23 Pepe, 25 Martinez
Inter: 1 Julio Cesar; 13 Maicon, 2 Cordoba, 15 Ranocchia, 4 Zanetti; 15 Kharja, 8 Thiago Motta, 19 Cambiasso; 10 Sneijder; 7 Pazzini, 9 Eto'o.
Inter bench: 12 Castellazzi, 20 Obi, 23 Materazzi, 27 Pandev, 29 Coutinho, 55 Nagatomo, 57 Natalino
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more