Mirko Vucinic has not recovered in time for Roma's trip to Genoa, while Marco Borriello is struggling and there are three suspensions.
The Giallorossi have a reduced strike force at Marassi on Sunday afternoon, as Vucinic is suffering from a right knee problem and has been left out of the squad.
Borriello is not 100 per cent fit either with back age, so Jeremy Menez could be pushed up to partner Francesco Totti with Fabio Simplicio in the trequartista role.
Daniele De Rossi, Marco Cassetti and Aleandro Rosi are all suspended with Adriano still in Brazil after dislocating his shoulder.
David Pizarro is in the squad and could make his first appearance of 2011.
Roma squad: Lobont, Julio Sergio, Doni; Juan, Castellini, Mexes, Loria, Riise, G Burdisso, N Burdisso; Pizarro, Taddei, Perrotta, Greco, Simplicio, Brighi, Pettinari; Totti, Borriello, Menez