Inter adopt a new 4-3-2-1 system with Wesley Sneijder and Dejan Stankovic supporting Samuel Eto'o against Bayern Munich.
Leonardo has his first Nerazzurri game in the Champions League in what is essentially a replay of the 2010 Final.
Much has changed from their last European outing, as January signing Andrea Ranocchia starts, with Yuto Nagatomo and Houssine Kharja on the bench.
Giampaolo Pazzini is ineligible, having played in this competition for Sampdoria in the preliminary round.
Diego Milito scored a brace back in May, but is on the treatment table, although ex-Bayern defender Lucio is fit again after a long lay-off and returns to the starting XI.
Cristian Chivu takes the left-back role, so Javier Zanetti is pushed up into midfield.
The big change is in attack, where Stankovic partners Sneijder in support of lone striker Eto'o.
Bayern are without Ivica Olic, Diego Contento and Rouven Sattelmaier, though Mario Gomez shook off an ankle injury to start at San Siro.
Thomas Kraft takes the gloves with Anatoliy Tymoshchuk surprisingly at centre-back.
Inter: Julio Cesar; Maicon, Ranocchia, Lucio, Chivu; Zanetti, Cambiasso, Thiago Motta; Sneijder, Stankovic; Eto'o
Inter bench: Castellazzi, Kharja, Mariga, Materazzi, Pandev, Coutinho, Nagatomo
Bayern Munich: Kraft; Lahm, Tymoshchuk, Badstuber, Pranjic; Schweinsteiger, Luiz Gustavo; Robben, Muller, Ribery; Gomez
Bayern bench: Butt, Breno, Van Buyten, Hamit Altintop, Ottl, Klose, Kroos