Esteban Cambiasso has strained the adductor muscle in his left thigh and will miss Inter's trip to Sampdoria this weekend.
The 30-year-old underwent a scan this morning after picking up the injury during Wednesday's Champions League match against Bayern Munich.
It's the third time that Cambiasso has been on the sidelines this season. Inter were also without him in October and towards the end of January.
Thiago Motta is another player who is doubtful to play on Sunday, while Andrea Ranocchia is out for 15 days after being stretchered off in midweek.